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目的探讨内镜下套扎术联合卡维地洛和普萘洛尔治疗食管静脉曲张出血的效果。方法 70例接受内镜下套扎治疗的食管静脉曲张出血患者作为研究对象,按平均分配法分为观察组和对照组,每组35例。联合卡维地洛治疗的患者为观察组,联合普萘洛尔治疗的患者为对照组,观察两组患者的并发症和临床疗效情况。结果治疗后两组患者的平均动脉压和心率比较,差异无统计学意义(P>0.05)。观察组患者的总出血率为37.24%,药物使用剂量(17.62±5.43)mg,明显优于对照组的14.29%、(96.31±19.35)mg,差异具有统计学意义(P<0.05)。观察组患者总有效率为97.14%,高于对照组的82.86%,差异具有统计学意义(P<0.05)。两组患者总不良反应发生率比较,差异无统计学意义(P>0.05)。结论食管静脉曲张出血患者应用内镜下套扎术联合卡维地洛治疗后出血情况得到有效控制、降低患者死亡率,值得临床推广使用。
Objective To investigate the effect of endoscopic ligation combined with carvedilol and propranolol in the treatment of esophageal variceal bleeding. Methods Seventy patients with esophageal varices bleeding under endoscopic ligation were divided into observation group and control group according to the average distribution method, with 35 cases in each group. The patients treated with combined carvedilol were observed and the patients treated with propranolol were the control group. The complication and clinical efficacy of the two groups were observed. Results There was no significant difference in mean arterial pressure and heart rate between the two groups after treatment (P> 0.05). The total bleeding rate was 37.24% in the observation group and 17.62 ± 5.43 mg in the control group, which was significantly better than that in the control group (14.29%, 96.31 ± 19.35 mg, P <0.05). The total effective rate in observation group was 97.14%, which was higher than that in control group (82.86%), the difference was statistically significant (P <0.05). The two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Esophageal variceal hemorrhage in patients with endoscopic ligation combined with carvedilol treatment of bleeding is effectively controlled to reduce the mortality of patients, it is worth promoting the use of the clinic.