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目的 观察国产冻干水痘减毒活疫苗的免疫效果。方法 在广西桂林市灌阳县和吉林省和龙市选择 1～ 6岁健康易感儿童接种国产冻干水痘减毒活疫苗 ,进行安全性、免疫原性观察 ;同时 ,选择与疫苗接种者密切接触的非接种者进行疫苗株传播性观察。结果 4 10名观察对象接种水痘疫苗后无明显副反应。检测有效血清 2 71份 ,血清抗体阳转率为 98 89% ,GMT为 1∶36 83。该疫苗株接种不存在传播性。结论 接种国产冻干水痘减毒活疫苗安全、有效
Objective To observe the immune effect of live attenuated vaccine of domestic freeze-dried varicella. Methods Guanyin County, Guilin City, Guilin Province and Heilongjiang Province, Jilin Province were selected healthy live-susceptible children aged 1 to 6 years to inoculate domestic attenuated live attenuated varicella vaccine to observe the safety and immunogenicity. At the same time, Non-vaccinated contacts were vaccinated for vaccine transmission. Results Four hundred and ten subjects had no obvious adverse reactions after receiving the chickenpox vaccine. A total of 2 71 validated serum samples were obtained. The seroconversion rate of serum antibody was 98.99% and the GMT was 1:36 83. Vaccination of the vaccine strain is not contagious. Conclusion It is safe and effective to inoculate domestic freeze-dried varicella live attenuated vaccine