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干扰素调节因子8(IRF8)是造血细胞中表达的转录因子,调控一系列转录因子的功能和表观遗传改变。在单核吞噬细胞祖细胞中,IRF8与富含嘌呤盒1(PU.1)联合促进末端增强子的形成,诱导单核细胞相关基因包括关键的下游Krüppel样因子4(KLF4)的表达,调节单核细胞的形成;IRF8还可以促进树突状细胞、嗜酸粒细胞和嗜碱粒细胞的形成;IRF8通过抑制CCAAT增强子结合蛋白α(C/EBPα)的活性来抑制中性粒细胞的分化程序从而抑制中性粒细胞的产生。IRF8-/-单核吞噬细胞祖细胞不能分化成单核细胞、吞噬细胞,反而异常引起中性粒细胞产生。IRF8-/-小鼠及IRF8表达缺失或突变的人都会表现出免疫缺陷和类慢性粒细胞性疾病。本文主要概括IRF8在髓系细胞形成及在相关疾病中重要作用。
Interferon regulatory factor 8 (IRF8) is a transcription factor expressed in hematopoietic cells that regulates the function and epigenetic changes of a range of transcription factors. In mononuclear phagocyte progenitor cells, IRF8 in combination with purinergic box-rich 1 (PU.1) promotes the formation of terminal enhancers, inducing the expression of monocyte-related genes including the key downstream Krüppel-like factor 4 (KLF4), regulating IRF8 can also promote the formation of dendritic cells, eosinophils and basophils; IRF8 can inhibit the activity of CCAAT enhancer binding protein α (C / EBPα) to inhibit neutrophil Differentiation program to inhibit neutrophil production. IRF8 - / - mononuclear phagocyte progenitor cells can not differentiate into monocytes, phagocytes, but unusually cause neutrophils. People with deficient or mutated IRF8 - / - mice and IRF8 express immunodeficiency and chronic myeloid diseases. This article summarizes the important role of IRF8 in the formation of myeloid cells and related diseases.