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小鼠于照前7天由肌内注射苯甲酸雌二醇,根据骨髓粒系祖细胞(CFU-D),内源性脾结节(CFU-S),以及骨髓细胞分裂指数和染色体畸变率的改变,探讨其对受照射小鼠造血功能的影响。在照射后的早期,不论CFU-D的数量或染色体畸变率,用药与对照组之间均未见有差异,而在照射后的第3、5、9天,给药组CFU-D的产率均比不用药的对照组有明显提高,而且,骨髓细胞分裂指数在照后3～5天亦高于对照组。上述结果提示,苯甲酸雌二醇的辐射防护作用主要不在减轻造血干细胞的辐射损伤,而与促进残存干细胞增殖有关。
Mice were injected intramuscularly with estradiol benzoate 7 days prior to irradiation, according to myeloid progenitor cells (CFU-D), endogenous splenic nodules (CFU-S), and myeloid cell division index and chromosome aberration rate The changes were explored to investigate its effect on hematopoietic function in irradiated mice. In the early post-irradiation period, regardless of the number of CFU-D or chromosomal aberrations, there was no difference between the drug and the control group, but on the 3rd, 5th, and 9th days after irradiation, the CFU-D was administered to the administration group. The rate was significantly higher than that of the control group without medication. Moreover, the bone marrow cell division index was also higher in the 3 to 5 days after irradiation than in the control group. The above results suggest that the radiation protection effect of estradiol benzoate is not mainly to reduce the radiation damage of hematopoietic stem cells, but to promote the proliferation of residual stem cells.