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临床经验证明,应用三联疗法根除幽门螺杆菌无效的原因是存在耐灭滴灵的菌株。因此,在根除幽门螺杆菌的治疗中,有必要除外灭滴灵。克拉霉素(clarithromycin)是一种新药,其耐受性更好。它是一种对酸性稳定的大分子抗生素,具有类似红霉素的抗菌谱[试管内抗Hp的最低抑制浓度90(MIC90)=0.03mg/L]。本项研究的目的是应用克拉霉素500mg/tds和洛赛克40mg/mane2周对幽门螺杆菌的清除率。
Clinical experience shows that the application of triple therapy for the eradication of Helicobacter pylori is invalid due to the presence of metronidazole resistant strains. Therefore, in the treatment of Helicobacter pylori eradication, it is necessary to exclude metronidazole. Clarithromycin is a new drug that is better tolerated. It is an acidic stable macromolecular antibiotic with an erythromycin-like antibacterial spectrum [minimum in vitro anti-Hp concentration of 90 (MIC90) = 0.03 mg / L]. The purpose of this study was to evaluate the clearance of Helicobacter pylori by clarithromycin 500 mg / tds and Losec 40 mg / mane 2 weeks.