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肺机械功能测定是整体动物实验中研究平喘药较好的方法。本文通过测定豚鼠的潮气量(V)、呼吸气流速度(F)和胸内压(P),描记压力—流速(P-F)曲线和压力—容量(P-V)曲线,计算肺阻力(R_L)和肺动态顺应性(Cdyn),研究艾叶油的有效平喘成分之一——α-萜品烯醇(α-Ter-pineol)对豚鼠气道的直接扩张作用,对豚鼠组胺引喘、卵白蛋白主动致敏和IgE抗血清被动致敏豚鼠实验性哮喘的保护作用,并且用心得安、利血平等工具药初步分析其作用机理,发现其作用并非通过兴奋β肾上腺素受体,亦不受肾上腺素能神经功能的影响。
Pulmonary mechanical function test is a better method to study antiasthmatic drugs in the whole animal experiment. In this paper, the lung resistance (R_L) and lungs were calculated by measuring the tidal volume (V), respiratory airflow velocity (F) and intrathoracic pressure (P) in guinea pigs and the pressure-flow rate (PF) curve and pressure- Dynamic compliance (Cdyn) was used to study the direct dilation effect of α-Ter-pineol on airway of guinea pig, which is one of the effective anti-asthmatic components of AI, Active sensitization and IgE antiserum passively sensitized guinea pig experimental asthma protective effect, and propranolol, reserpine and other drug preliminary analysis of its mechanism of action and found that its effect is not excited by β-adrenergic receptor, nor by epinephrine Can affect the function of nerves.