本文报告大剂量浓缩因子Ⅷ治疗一例抗体浓度很高的获得性血友病,引起严重溶血性贫血及肝萎缩。获得性血友病是一种罕见的出血性疾病,临床表现与血友病相似,因血浆中自发地产生大量因子Ⅷ抗体而引起出血。本例在34天内共用浓缩因子Ⅷ156.5单位,分8次输注,引起严重溶血性贫血,显然是因制剂中含有抗红细胞某些抗原的抗体。抗人球蛋白试验(一),可能因在红细胞表面附着的免疫球蛋白(ZgG)少于500个分子所致阴性反应,另一点值得注意的此病人死后尸检肝脏软小仅800克,肝脏萎缩、坏死很可能是因子Ⅷ中含 This article reports the high dose of concentrated factor Ⅷ treatment of a high antibody concentration of acquired hemophilia, causing severe hemolytic anemia and liver atrophy. Acquired hemophilia is a rare hemorrhagic disease with clinical manifestations similar to haemophilia and bleeding caused by the spontaneous production of a large number of factor VIII antibodies in the plasma. In this case, the concentration factor VIII156.5 unit is shared for 34 days, and the infusion is divided into 8 times to cause severe hemolytic anemia. Apparently, the preparation contains antibodies against certain antigens of erythrocytes. Anti-human globulin test (a), may be due to the surface of red blood cells attached to immunoglobulin (ZgG) less than 500 molecules caused by negative reactions, it is also worth noting that the post-mortem hepatic soft tissue of the deceased was only 800 grams, liver Atrophy, necrosis is likely to factor Ⅷ