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在肿瘤的化学治疗中,静脉注入抗癌药物,全身副作用较大,局部药物浓度较低,从而影响疗效的提高。选择肿瘤的营养动脉,注射抗癌药物是用药的新途径,自1950年以来,向局部区域性灌注及局部动脉内持续注射两个方向发展。1959年 Sullivan 等开始报道用代谢拮抗剂 MTX 对头颈部肿瘤进行持续动脉内注射疗法,得到显著疗效。我国肿瘤工作者自1960年起开展间断动脉内注射抗癌药物治疗恶性肿瘤的工作,1965年即有以药瓶高悬的方法进行动脉内持续滴注抗癌药物治疗恶性肿瘤的报道。动脉内持续注射抗癌药物具
In the chemotherapy of tumors, intravenous anti-cancer drugs are injected into the body. The systemic side effects are large and the local drug concentration is low, which affects the improvement of the therapeutic effect. Selecting the nutrient artery of the tumor and injecting anti-cancer drugs is a new approach to medication. Since 1950, it has been developed in two directions: local regional perfusion and continuous intra-arterial injection. In 1959, Sullivan et al. began to report on the continuous intra-arterial injection of head and neck tumors with the metabolic antagonist MTX. Since 1960, oncologists in our country have carried out intermittent intra-arterial injection of anti-cancer drugs for the treatment of malignant tumors. In 1965, there were reports of continuous instillation of anticancer drugs in the artery to treat malignant tumors. Continuous injection of anticancer drugs in the artery