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江泉观等认为,TNT 是氧化性应激毒物。生物学后果可能为细胞内钙稳态紊乱与脂质过氧化。磷酸化酶a 的活性与细胞内钙稳态有关。磷酸化酶是糖元分解的限速酶,胞浆Ca~(++)浓度是调节磷酸化酶活性的因素之一。本实验通过测定TNT 接触者和染毒大鼠血清磷酸化酶a 活性的
Jiangquan view that TNT is oxidative stress poison. Biological consequences may be intracellular calcium homeostasis and lipid peroxidation. Phosphorylase activity is related to intracellular calcium homeostasis. Phosphorylase is the rate-limiting enzyme for glycogenolysis, and cytoplasmic Ca ~ (++) concentration is one of the factors that regulate phosphorylase activity. In this experiment, the activity of serum phosphorylase-a in TNT-exposed and exposed rats was determined