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作者用500条曼氏血吸虫尾蚴经皮肤感染小鼠,用杀童虫药物RO11-3128将感染终止在皮肤移行期,然后分别于终止感染后5wk和16wk行攻击感染,3wk后冲击。结果表明:RO11-3128所诱导的抗曼氏血吸虫的保护性免疫力与20krad照射尾蚴免疫的相似,分别为73％和61％(5wk)及51％和71％(16wk),这种免疫力是种特异性的,对日本血吸虫无效(保护力仅为7％)。用RO15-5458(一种类似于RO11-3128,具有杀童虫作用的化合物)将感染终止于皮肤移行期,结果也诱导了抗曼氏血吸虫的保护性免疫力,但保
The authors used 500 S. mansoni cercariae to infect mice via skin. The infection was terminated at the skin transition stage with the disinfectant drug RO11-3128, and then challenged at 5 and 16 weeks after the termination of infection, respectively, and challenged after 3 weeks. The results showed that the protective immunity induced by RO11-3128 against Schistosoma mansoni was similar to that of 20krad irradiated cercariae, which were 73% and 61% (5wk) and 51% and 71% (16wk), respectively Species specific, not effective against Schistosoma japonicum (protection only 7%). With RO15-5458, a compound that acts as a sperm-killing agent similar to RO11-3128, terminates the infection at the skin transitional stage and as a result also induces protective immunity against Schistosoma mansoni,