论文部分内容阅读
近来发现,IL_2与人外周血单个核细胞(PBMC)共育可诱导产生对多种瘤细胞有杀伤作用的淋巴因子活化杀伤细胞(lymphokine-activated killer cells,LAK);最近,作者们又发现,具极高NK活性的人Leu7~-11~+颗粒淋巴细胞在重组IL_2(γIL_2)中可增殖并发育为对新鲜瘤细胞有细胞毒的活化杀伤细胞(AK).富含NK细胞的PBMC经IL_2刺激时也能产生IFNγ并发育为AK型细胞毒,表明由IL_2诱导产生AK是需要IFNγ的.为此,本文研究IFNγ在γIL_2诱导产生AK中的作用.结果首先发现,γIL_2与PBMC共育后诱
Recently, it has been found that co-culture of IL-2 with human peripheral blood mononuclear cells (PBMCs) induces the production of lymphokine-activated killer cells (LAK), which have a killing effect on many tumor cells. Recently, Human Leu7 ~ -11 ~ + granulocytes with very high NK activity can proliferate and develop into cytotoxic activated killer cells (AKs) in fresh tumor cells in recombinant IL_2 (γIL_2). NK cell-rich PBMCs IL-2 can also produce IFNγ and develop into AK-type cytotoxicity, indicating that the production of AK by IL-2 is required for IFNγ.Therefore, we studied the role of IFNγ in AKI-induced AKI.Results First of all, it was found that γIL_2 co-cultured with PBMC After the temptation