当接受到特异性的抗原刺激后,CD4+T细胞将会启动激活与分化的进程,从而进入免疫效应阶段。目前已知的效应性CD4+T细胞包括Th1,Th2,Th17,Tfh,以及一类起负向调节作用的“调节性T细胞”(regulatory T cell,Treg)。免疫学领域一致认为,CD4+T细胞的分化方向主要是由几种转录因子分别决定的:T-bet控制T细胞分化成为Th1,GATA-3控制T细胞分化成为Th2,RORγt决定T细胞分化成为Th17,而Treg的代表性转录因子是Fox P3。由于对于每一个T细胞来说,分化的命运只有一 When receiving specific antigen stimulation, CD4 + T cells will start the process of activation and differentiation, and thus enter the immune response phase. Currently known effector CD4 + T cells include Th1, Th2, Th17, Tfh, and a class of regulatory T cells (Tregs) that play a negative regulatory role. In the field of immunology, it is agreed that the direction of differentiation of CD4 + T cells is mainly determined by several transcription factors respectively: T-bet controls T cell differentiation to Th1, GATA-3 controls T cell differentiation to Th2, and RORγt determines T cell differentiation to be Th17, whereas Treg’s representative transcription factor is Fox P3. Because for every T cell, the fate of differentiation is only one