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目的:分析某院乙型肝炎患者血清检测指标HBe Ag和HBe Ab阳性的检查结果及其防治对策,为临床诊治提供参考。方法:采用发光酶免法检测1 250例乙型肝炎患者血液标本中HBe Ag和HBe Ab浓度,分析其阳性的原因,尤其是对HBe Ag阳性与HBe Ab阳性患者的发病机制和防治对策。结果:1 250例患者中,其中957例患者检查结果有11种模式,94例患者HBs Ag阳性中HBe Ag和HBe Ab为双阳性模式占7.52%,74例患者为HBe Ag和HBe Ab单独或共同处于阳性临界范围占HBe Ag和HBe Ab双阳性模式的78.72%,其他模式为125例占10.00%;随着HBe Ag值下降,HBe Ab值上升,提示HBe Ag趋向HBe Ab转换。结论:中医辅助治疗对乙型肝炎患者血清HBe Ag向HBe Ab转阴有较好的疗效;随着检测技术的进步,乙型肝炎病毒学指标的检测灰区越来越小,监测病毒学检测指标对乙型肝炎患者的临床治疗更具有指导意义。
OBJECTIVE: To analyze the positive results of HBeAg and HBeAb in the serum of hepatitis B patients from a hospital and its prevention and cure measures, so as to provide reference for clinical diagnosis and treatment. Methods: The concentrations of HBeAg and HBe Ab in blood samples of 1,250 patients with hepatitis B were assayed by enzyme-linked immunosorbent assay (ELISA). The pathogenesis and prevention and treatment of HBeAg-positive and HBe-Ab-positive patients were analyzed. Results: Of the 1,250 patients, 11 of 957 patients had 11 patterns of HBsAg-positive HBeAg-positive and HBe-Ab positive double-positive patterns accounting for 7.52%, 74 were HBe Ag and HBe Ab alone or in combination 78.72% of HBe Ag and HBe Ab double positive model in the positive critical range, 125.00% and 10.00% in other models. As the HBe Ag value decreased, the value of HBe Ab increased, suggesting that HBeAg tended to HBe Ab conversion. Conclusion: Chinese medicine adjuvant therapy has a good curative effect on the serum HBe Ag negative to HBe Ab in patients with hepatitis B. With the progress of detection technology, the detection gray area of hepatitis B virology index is getting smaller and smaller, and the detection of virological test Indicators on the clinical treatment of hepatitis B patients more instructive.