论文部分内容阅读
端粒是真核细胞线性染色体末端的DNA重复序列和特异结合蛋白的复合体 ,对维持染色体的稳定性和完整性具有重要作用。端粒酶是一种由RNA和蛋白质组成的核糖核蛋白复合体 ,具有逆转录酶的活性。许多研究表明 ,端粒和端粒酶系统调控着细胞增殖活性和细胞寿命。本文介绍了端粒、端粒酶的研究进展以及其在某些皮肤病和肿瘤发生与发展中的作用。
Telomere is a complex of DNA repeats and specific binding proteins at the end of linear chromosomes of eukaryotes and plays an important role in maintaining the stability and integrity of chromosomes. Telomerase is a ribonucleoprotein complex composed of RNA and protein, which has reverse transcriptase activity. Numerous studies have shown that the telomere and telomerase systems regulate cell proliferation activity and cell lifespan. This article introduces the research progress of telomere and telomerase and its role in the occurrence and development of some dermatological diseases and tumors.