Objectives To report the clinical experiences of rnsrmultaneous hepatorenal transplantation.rnMethods We performed simultaneous hepatorenal rntransplantation in one patient with liver cirrhosis of rnhepatitis B and uremia of chronic nephritis on February rn1,1999 and one patient with liver cirrhosis of hepatitis rnB complicated by hepatorenal syndrome on March 12,rn1999.The donors were heart arrest cases. Rapid rnmultiple organ harvesting techniques and UW solution rninfusion in situ were used. Liver and kidney rntransplantation were orthotopic and ordinary methods,rnrespectively. Immunosuppressive drugs consisted of rncyclosporine, Cellcept, ALG and sortstso steroids.rnLamividine was used os day 50 and day 40rnpostoparation, respectively.rnResults Both transplanted organs rapidly achieved rnnormal function postoperation and the patients rnrecovered well but suffered mild kidney rejection day rn110 postopemtion in No 1 patient. In No 2 patient,rnacute renal function failure, mental symptoms, muscle rnspasm,cerebral artery thrombosis, inhalation rnpoeumonia and chronic liver graft rejection ensured rnsequentially but were controlled.The patients have rnsurvived for more than nine and eight months,rnrespectively, with normal life quality.rnConclusions Combined hepatorenal transplant is a rnradical treatment method for liver and kidney function rnfailure and requires more comprehensive techniques rnthan isolated single organ transplantation.Preventing rnthe recurrence of hepatitis B by oral lamividine may be rna kdy to long-term survival.