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目的:研究托吡酯联合丙戊酸钠治疗难治性癫痫的临床疗效。方法:选取收治的难治性癫痫患者101例,随机分为对照组50例与观察组51例。对照组采用托吡酯治疗,观察组在此基础上添加丙戊酸钠联合治疗。结果:用药后两组患者癫痫发作次数较用药前均有所改善,且观察组改善情况明显优于对照组;两组患者用药后不良反应发生率差异均无统计学意义;观察组治疗总有效率为92.16%,明显高于对照组(72.00%)。结论:托吡酯联合丙戊酸钠对难治性癫痫患者的临床治疗效果非常显著,可有效减少癫痫发作次数,提高治疗效果,且未增加不良反应。
Objective: To study the clinical efficacy of topiramate plus valproate in treatment of refractory epilepsy. Methods: A total of 101 refractory epilepsy patients were randomly divided into control group (n = 50) and observation group (n = 51). The control group was treated with topiramate, the observation group was added on the basis of sodium valproate combination therapy. Results: The number of epileptic seizures in both groups improved after treatment, and the improvement in the observation group was better than that in the control group. There was no significant difference in the incidence of adverse reactions between the two groups after treatment. Efficiency was 92.16%, significantly higher than the control group (72.00%). Conclusion: Topiramate combined with sodium valproate has a significant clinical effect on patients with refractory epilepsy, which can effectively reduce the number of seizures and improve the therapeutic effect without increasing adverse reactions.