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近年的研究认识到,过敏反应时化学介质的释放在过敏性疾病发病中起十分重要的作用,这些介质的释放是某些过敏性疾病炎症反应的中心环节之一。因此对能合成和释放这些介质的嗜碱粒细胞和肥大细胞进行研究,是探讨过敏性疾病的一个重要方面。由于外周血嗜碱粒细胞极易获取,且很早就发现嗜碱粒细胞在体外对抗原的敏感性和机体过敏反应的严重性呈平行关系,因而Lichtenstein等选择嗜碱粒细胞系统作为人类过敏反应的体外实验模型,并提出“人嗜碱粒细胞释放能力(Human Basophil
Recent studies have realized that the release of chemical mediators during anaphylactic reactions plays a very important role in the development of allergic diseases. The release of these mediators is one of the key links in the inflammatory response of some allergic diseases. Therefore, the study of basophils and mast cells, which synthesize and release these mediators, is an important aspect to explore allergic diseases. Since peripheral blood basophils are readily available and it has long been found that the sensitivity of basophils to antigens in vitro is in parallel with the severity of the anaphylactic reaction, Lichtenstein et al. Chose the basophil system as a human allergy Response in vitro model and proposed "human basophil release capacity (Human Basophil