论文部分内容阅读
目的探讨HBsAg(+)/核酸检测(nucleic acid test,NAT)(-)献血者的乙肝表面抗原(hepatitis B surface antigen,HBsAg)定量水平和血清学特征。方法对104名HBsAg(+)/NAT(-)献血者进行HBsAg定量检测和HBV两对半检测,对HBsAg定量结果进行统计学描述,比较不同HBV血清学模式组的HBsAg定量。结果广州地区HBsAg(+)/NAT(-)献血者在无偿献血者中的占比为0.19%,在HBsAg双试剂确认阳性献血者中的占比为24.87%;HBsAg定量均处于中低水平并以低水平(HBsAg<100 IU/m L)为主(97.12%,101/104),中位数为1.16 IU/m L;两对半检测均为HBeAg阴性,共出现8种血清学组合模式,以小三阳“145”模式最多(56.73%,59/104);HBsAb阳性者较单HBeAb阳性者的HBsAg定量低,差异具有统计学意义(P<0.05)。结论获得HBsAg(+)/NAT(-)献血者的HBsAg定量水平和血清学特征,为评价其血液安全性提供了一定的实验依据。
Objective To investigate the quantitative and serological characteristics of hepatitis B surface antigen (HBsAg) in blood donors with HBsAg (+) / nucleic acid test (NAT) (-). Methods A total of 104 HBsAg (+) / NAT (-) blood donors were tested for HBsAg and HBsAg in two and a half cycles. The quantitative results of HBsAg were statistically analyzed and the HBsAg levels of different HBV serological models were compared. Results The proportion of HBsAg (+) / NAT (-) blood donors was 0.19% in Guangzhou and 24.87% in HBsAg-positive donors. The HBsAg quantification was at low to moderate levels The lowest level (HBsAg <100 IU / mL) was 97.12% (101/104) with a median of 1.16 IU / mL. Two pairs of tests were negative for HBeAg, and eight serological combinations (56.73%, 59/104) respectively. The HBsAg of HBsAb-positive patients was lower than that of HBeAb-positive patients (P <0.05). Conclusion The quantitative and serological characteristics of HBsAg obtained from blood donors with HBsAg (+) / NAT (-) donor provide some experimental evidence for evaluating blood safety.