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目的：探讨及研究胃蛋白酶原在体检胃病及胃癌筛查中的应用价值。方法：选取2013年1月~2014年12月的体检和住院的70例胃癌患者为A组，70例胃溃疡患者为B组，70例胃炎患者为C组，70名健康人员为D组，然后将四组人员的血清胃蛋白酶原相关指标进行检测及比较，并比较A组中不同分期患者的检测结果，同时以Logistic分析研究指标与胃癌的关系。结果：A组级C组的血清PGⅠ及PGⅠ/PGⅡ均低于D组，阳性率高于D组，B组的血清PGⅠ及PGⅡ则均高于D组，PGⅠ/PGⅡ则低于D组， A组中不同分期患者的血清PGⅠ及PGⅠ/PGⅡ也有显著性差异，且经Logistic分析显示，PGⅠ及PGⅠ/PGⅡ与胃癌有密切的关系， P均＜0.05。结论：胃蛋白酶原在体检胃病及胃癌筛查中的应用价值较高，对于胃病的诊断有一定的临床意义。“,”Objective To investigate and study the application value of pepsinogen in the physical examination of gastrosia and gastric cancer screening.Methods 70 patients with gastric cancer in the physical examination from January 2013 to December 2014 were selected as group A,70 patients with gastric ulcer were selected as group B,70 patients with gastritis were selected as group C and 70 healthy persons were selected as group D,then the serum pepsinogen related indexes of four groups were detected and compared,and the detection results of group A with different stages were detected and compared,then the relationship between the study indexes and gastric cancer were analyzed by the Logistic analysis. Results The serum PGⅠand PGⅠ/PGⅡof group A and group C were all lower than those of group D,the positive rates were higher than those of group D,the serum PGⅠand PGⅡaof group B were all higher than those of group D,PGⅠ/PGⅡwas lower than that of group D,and the serum PGⅠand PGⅠ/PGⅡof group A with different stages had significant differences,and the PGⅠand PGⅠ/PGⅡhad close relationship to the gastric cancer,all P<0.05.Conclusion The application value of pepsinogen in the physical examination of gastrosia and gastric cancer screening are high,and it has certain clinical significance for the diagnose of stomach diseases.