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目的:探讨滋阴潜阳方对高血压的降压作用及调节机制。方法:采用两肾一夹法复制大鼠肾性高血压模型,放免法检测各组大鼠血清IL-6、IL-8水平的变化。结果:模型组大鼠血清IL-6、IL-8含量明显增加,滋阴潜阳方对此有抑制作用。结论:滋阴潜阳方对血清IL-6、IL-8水平的抑制作用可能是其发挥神经免疫调节作用的机制之一。
Objective: To investigate the antihypertensive effect and regulation mechanism of Ziyinqianyang prescription on hypertension. Methods: The model of renal hypertension was established by two kidneys and one clip. The levels of IL-6 and IL-8 in serum of rats in each group were determined by radioimmunoassay. Results: Serum levels of IL-6 and IL-8 in the model group were significantly increased, and Ziyinqianyang Decoction inhibited this effect. Conclusion: The inhibitory effect of Ziyinqianyang Recipe on serum IL-6 and IL-8 levels may be one of the mechanisms of its neuroimmunologic regulation.