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目的:观察呋塞米联合甘露醇治疗高血压脑病的疗效及安全性。方法:对42例高血压脑病患者从入院时即予呋塞米20 mg静脉注射,20%甘露醇250 mL静滴联合治疗,动态评估患者血压变化和临床症状改善情况,并观察其不良反应。结果:42例高血压脑病患者在用药(25±5)min后开始自觉症状改善;舒张压和平均压缓慢下降,30 min后出现明显下降;60 min时所有患者均达到目标血压;未发现明显不良反应。结论:呋塞米联合甘露醇在降低颅内压的同时,能平稳降低血压,简单、便捷、安全,可应用于无合并严重肾衰、心衰的高血压脑病患者。
Objective: To observe the efficacy and safety of furosemide combined with mannitol in the treatment of hypertensive encephalopathy. Methods: 42 patients with hypertensive encephalopathy were given intravenous injection of 20 mg furosemide and 250 mL intravenous infusion of 20% mannitol to assess the changes of blood pressure and clinical symptoms in patients with hypertensive encephalopathy. The adverse reaction was observed. Results: The symptoms of 42 patients with hypertensive encephalopathy started to improve after 25 ± 5 min of administration. The diastolic and mean pressures slowly decreased and decreased significantly after 30 min. All patients reached the target blood pressure at 60 min. No significant changes were found Adverse reactions. Conclusions: Furosemide combined with mannitol can reduce blood pressure smoothly while reducing intracranial pressure. It is simple, convenient and safe and can be applied to patients with hypertensive encephalopathy without severe renal failure and heart failure.