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用卵磷脂/丙酮沉淀法测定经部分纯化的人胚肝LDL受体活性,结果发现,随着胎龄增加,肝脏LDL受体活性明显增高。与此同时,血清总胆固醇(TC)和LDL-胆固醇(LDL-C)水平进行性下降。胎龄与血清TC和LDL-C的相关系数分别为-0.80和-0.77,有显著意义(P<0.001)。进而发现,在胚肝LDL受体活性与血清TC和LDL-C之间也存在着明显的负相关,相关系数分别为-0.96和-0.95(P<0.001)。这一结果提示,在胎儿发育过程中,肝脏LDL受体对血胆固醇水平调节起着关键的作用。
LDL receptor activity in partially purified human embryonic liver was determined by lecithin / acetone precipitation and found that liver LDL receptor activity was significantly increased with increasing gestational age. At the same time, levels of serum total cholesterol (TC) and LDL-cholesterol (LDL-C) decreased progressively. Correlation coefficients between gestational age and serum TC and LDL-C were -0.80 and -0.77, respectively (P <0.001). Furthermore, it was found that there was also a significant negative correlation between LDL receptor activity in embryonic liver and serum TC and LDL-C with correlation coefficients of -0.96 and -0.95, respectively (P <0.001). This result suggests that liver LDL receptors play a key role in the regulation of blood cholesterol levels during fetal development.