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目的该文就激素联合环磷酰胺治疗系统性红斑狼疮合并狼疮肾炎的应用效果进行研究。方法选取该院在2015年9月—2017年2月期间收治的32例系统性红斑狼疮合并狼疮肾炎患者,按照随机数字表法分为实验组与参照组,各16例。参照组单纯采用激素治疗,实验组予以激素联合环磷酰胺治疗,比较两组患者的治疗总有效率及实验室指标。结果实验组患者的治疗总有效率对比参照组更高,实验组的尿蛋白、尿红细胞、血清肌酐以及红细胞沉降率等指标均优于参照组,经统计两组患者的不良反应发生率比较差异(P>0.05)。结论应用素联合环磷酰胺治疗系统性红斑狼疮合并狼疮肾炎具有理想效果,可促使患者症状消退,且不良反应少,安全性高,值得推广。
Objective To study the effect of hormone combined with cyclophosphamide in the treatment of systemic lupus erythematosus complicated with lupus nephritis. Methods Twenty-two patients with systemic lupus erythematosus and lupus nephritis admitted to our hospital from September 2015 to February 2017 were divided into experimental group and control group according to the random number table method, and each group had 16 cases. The reference group was treated with steroid alone. The experimental group was treated with hormones combined with cyclophosphamide. The total effective rate and laboratory indexes of the two groups were compared. Results The total effective rate of treatment group was higher than that of the reference group. Urinary protein, urinary red blood cells, serum creatinine and erythrocyte sedimentation rate in the experimental group were better than the reference group. The incidence of adverse reactions in the two groups were statistically different (P> 0.05). Conclusion Combination of cyclophosphamide and cyclophosphamide in the treatment of systemic lupus erythematosus with lupus nephritis has the ideal effect, can promote the symptoms of patients subsided, and less adverse reactions, high safety, it is worth promoting.