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目的 :探讨老年冠心病患者红细胞免疫功能与胰岛素抵抗 (IR)之间的关系。方法 :将老年冠心病人 (4 9例 )分为不稳定型心绞痛组 (2 7例 )和稳定型心绞痛组 (2 2例 ) ,并与 32例健康老人组对照。采用“郭峰改良法”及PEG双抗法分别检测各组的红细胞C3b受体花环 (RBC C3bRR)、红细胞免疫复合物花环率 (RBC ICR)及空腹和餐后 2h胰岛素 (IS)。结果 :老年冠心病组RBC ICR、空腹及糖负荷后的IS均明显高于对照组 ,P <0 .0 1,尤以不稳定型心绞痛组为甚 ;空腹及糖负荷后的IS与RBC ICR间均呈明显正相关性 ,r=0 .31、r =0 .38、P <0 .0 1。老年冠心病组RBC C3bRR与对照组无显著性差异。结论 :RBC ICR和IR参与老年冠心病的发病过程 ,并相互影响 ,加重血管内皮的损伤。
Objective: To investigate the relationship between erythrocyte immune function and insulin resistance (IR) in elderly patients with coronary heart disease. Methods: The elderly patients with coronary heart disease (49 cases) were divided into unstable angina pectoris group (27 cases) and stable angina pectoris group (22 cases), and 32 healthy controls. The RBC C3bRR, RBC ICR and fasting and postprandial 2h insulin (IS) of each group were detected by “Guo Feng Modified Method” and PEG double antibody method respectively. Results: The RBC ICR, fasting and post-glycemic load IS in elderly patients with coronary heart disease were significantly higher than those in the control group (P <0.01), especially in patients with unstable angina pectoris; IS and RBC ICR There was a significant positive correlation between r = 0.31, r = 0.38, P <0.01. RBC C3bRR in elderly patients with coronary heart disease and control group no significant difference. Conclusion: RBC ICR and IR are involved in the pathogenesis of senile coronary heart disease and affect each other and aggravate the injury of vascular endothelium.