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青蒿素临床上主要用于抗疟原虫疾病。我室用膜片钳研究发现 ,青蒿素具有浓度依赖性抑制家兔心室肌细胞IK1。用基因钳研究证明 ,给予非洲蛙卵母细胞注射Iir2 .1cRNA后 ,青蒿素对Kir2 .1/IK1有明显抑制作用。IK1及Kir2 .1和心肌动作电位复极末期有关 ,和心律失常的发生发展有密切
Artemisinin is mainly used clinically for anti-plasma disease. My laboratory patch clamp study found that artemisinin concentration-dependent inhibition of rabbit ventricular myocytes in IK1. The use of gene clamp studies demonstrated that artemisinin significantly inhibited Kir2.1/IK1 after injection of Iir2.1cRNA into African frog oocytes. IK1 and Kir2.1 are associated with the terminal stage of the repolarization of cardiac action potential, and are closely related to the occurrence and development of arrhythmia.