重型颅脑外伤并发上消化道出血,是一种常见的严重并发症,将对预后产生极大的影响,1932年Cushing等首次报道了11例颅内疾病患者发生消化道溃疡及穿孔,后称为“Cush-ing溃疡”。国内外有大量的文献报道了其发病机制及防治研究的结果,现就其研究结果综述如下。1发病机制:Cushing溃疡 Severe craniocerebral trauma complicated by upper gastrointestinal bleeding, is a common serious complication, will have a great impact on prognosis, 1932 Cushing et al first reported in 11 cases of intracranial disease in patients with peptic ulcer and perforation, said For “Cush-ing ulcer.” A large number of domestic and foreign literatures reported the pathogenesis and prevention and treatment of the results, the results of their research are summarized below. 1 pathogenesis: Cushing ulcer