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牙周膜是位于牙根与牙槽骨之间的结缔组织,具有自我更新和多向分化的能力。无论是在正畸治疗还是在牙周组织修复及再生过程中,牙周膜的成骨分化都是必不可少的。近年来,许多国内外学者致力于研究影响牙周膜成骨分化的因素,包括机械力,细胞因子,药物等,这些因素可以单独作用于牙周膜,也可以联合使用加快牙周膜成骨分化,可以为临床上加快牙齿移动和修复牙周组织缺损提供更多新的思路。现就影响牙周膜成骨分化的诸多因素及其主要机制作一综述。
The periodontal ligament is a connective tissue located between the root and the alveolar bone, with the ability to self-renew and differentiate into multiple directions. Osteogenic differentiation of the periodontal ligament is essential both in orthodontic treatment and in periodontal tissue repair and regeneration. In recent years, many domestic and foreign scholars devoted themselves to studying the factors that affect the periodontal membrane osteogenic differentiation, including mechanical force, cytokines, drugs, these factors can act on the periodontal ligament alone, can also be combined to accelerate the periodontal ligament Differentiation can provide more new ideas for accelerating tooth movement and repairing periodontal tissue defects clinically. Now on the impact of periodontal ligament osteogenic differentiation of many factors and their main mechanisms are reviewed.