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U-76252(CS-807)是U-76253(R-3746)的前体药物,为一广谱头孢菌素,能抑制许多β-内酰胺酶的水解,具有杀菌作用。本研究比较了U-76253与其它口服抗菌剂对各种需氧和厌氧菌的体外抗菌活性。研究所用的菌株从美国俄亥俄州立大学医院的患者中分离,共664株,包括从呼吸道分泌物中分离的流感嗜血菌株(47株β-内酰胺酶阴性和50株β-内酰胺酶阳性),粘膜炎布兰汉氏球菌(6株β-内酰胺酶阴性和14株β-内酰胺酶阳性)及脓性链球菌;从泌尿道分离的腐生性葡萄球菌;其他菌株中70％是从血液培养得到的。
U-76252 (CS-807) is a prodrug of U-76253 (R-3746), a broad-spectrum cephalosporin that inhibits the hydrolysis of many β-lactamases and has a bactericidal effect. This study compared the in vitro antibacterial activity of U-76253 and other oral antibacterials against various aerobic and anaerobic bacteria. Strains used in the study were isolated from patients at the Ohio State University Hospital in the United States of 664 strains, including H. influenzae isolates (47 β-lactamase negative and 50 β-lactamase positive) isolated from respiratory secretions, , M. catarrhalis (6 β-lactamase negative and 14 β-lactamase positive), and Streptococcus pyogenes; Staphylococcus aureus isolated from the urinary tract; 70% of other strains were derived from Blood culture got.