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将Ｗｉｓｔａｒ大鼠分为三组：肝硬化组，给予四氯化碳等复合因素；给药组，除给ＣＣｌ４等复合因素外，用赤栀黄合剂灌胃４１天；正常组给以一般饮食及饮水，结果，与正常组及给药组相比，硬化组血Ｔ３、Ｔ４测定值低，甲状腺滤泡中胶质明显减少，滤泡细胞与胶质间空泡增多，滤泡上皮细胞内ＰＡＳ阳性小滴数目增多。表明在实验性肝硬化期间甲状腺参与了抗疾病的代谢活动。其机理可能是肝硬化时肝细胞合成、转运Ｔ３、Ｔ４的蛋白质减少，运输中的Ｔ３、Ｔ４减少，活性甲状腺素不足，从而导致甲状腺代偿性功能活跃。赤栀黄合剂具有保肝，恢复甲状腺素水平的作用。
The Wistar rats were divided into three groups: cirrhosis group, given carbon tetrachloride and other complex factors; drug group, in addition to CCl4 and other complex factors, with Zhi Zhi Huang mixture gavage for 41 days; normal group to the general diet And drinking water, the results, compared with the normal group and the administration group, the measured value of serum T3 and T4 in the sclerotic group is low, the glial of the thyroid follicle is obviously reduced, the vacuoles between the follicular cells and the glial are increased, the follicular epithelial cells PAS-positive droplets increased. Suggesting that the thyroid is involved in anti-disease metabolic activity during experimental cirrhosis. The mechanism may be cirrhosis of liver cells synthesis, transport T3, T4 protein reduction, transport T3, T4 reduction, lack of active thyroxine, resulting in thyroid compensatory activity. Red Zhihuang mixture with liver, restore the role of thyroid hormone levels.