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[Objective]To discuss the protection effects of rutaecarpine(Rut)on the acute myocardial ischemia injury of tested animal.[Methods]Acute myocardial ischemia model of mice induced by pituitrin and isoproterenol was established.The activities of lactate dehydrogenase(LDH)and creatine kinase(CK)in serum were detected.The rat model of coronary artery ligation was adopted.The hemodynamic parameters were detected,as well as the serum LDH,CK,superoxide dismutase(SOD)and malondialdehyde(MDA).[Results]Compared with model group,Rut group could reduce the increase of serum LDH and CK in mice induced by pituitrin and isoproterenol(P<0.05).In the rat model of coronary artery ligation,Rut group could improve the changes of hemodynamic parameters in rats;the LDH and CK activities and MDA content in serum reduced,while SOD activity enhanced(P<0.05),compared with model group.[Conclusions]Rut had certain protection effects on the acute myocardial ischemia injury of tested animal.
[Methods] To discuss the protection effects of rutaecarpine (Rut) on the acute myocardial ischemia injury of tested animal. [Methods] Acute myocardial ischemia model of mice induced by pituitrin and isoproterenol was established. The activities of lactate dehydrogenase (LDH) and creatine kinase (CK) in serum were detected. The rat model was coronary artery ligation was adopted. The hemodynamic parameters were detected, as well as the serum LDH, CK, superoxide dismutase (SOD) and malondialdehyde (MDA) model group, Rut group could reduce the increase of serum LDH and CK in mice induced by pituitrin and isoproterenol (P <0.05) .In the rat model of coronary artery ligation, Rut group could improve the changes of hemodynamic parameters in rats; the LDH and CK activities and MDA content in serum reduced, while SOD activity enhanced (P <0.05), compared with model group. [Conclusions] Rut had certain certain protection effects on the acute myocardial ischemia injury of tested animal.