目的　探讨放射治疗 +化疗预防肌层侵犯的浸润性膀胱癌保存膀胱术后复发的疗效。方法　 2 3例肌层侵犯的浸润性膀胱移行细胞癌保存膀胱术后在丝裂霉素规则膀胱灌注化疗的基础上行放射治疗 (研究组 ) ,照射平均剂量为 5 2 .5Gy。以 2 9例同期同样病变行保存膀胱术后单纯丝裂霉素规则膀胱灌注化疗的为对照 (对照组 )。结果　研究组除 2例因放射性膀胱炎分别中断 3d和 1周后继续治疗外 ,其余均按计划完成治疗。所有病例随访 3年以上 ,平均随访 41.6个月。研究组和对照组 3年盆腔复发率为 18.8%和 44 .8% (P =0 .0 2 6 ) ;3年远地转移率分别为 18.2 %和 2 4.1% (P=0 .437) ;3年生存率分别为 81.8%和 86 .2 % (P =0 .6 70 )。结论　保存膀胱术后放射 +化疗治疗能有效降低肌层侵犯浸润性膀胱癌盆腔复发率 ,是膀胱癌保存膀胱术后理想的辅助治疗 Objective To investigate the curative effect of radiotherapy + chemotherapy in preventing recurrence of invasive bladder cancer after invasive bladder cancer. Methods Twenty-three cases of invasive bladder transitional cell carcinoma invading the muscular layer were treated with radiation therapy (study group) on the basis of mitomycin regular bladder infusion chemotherapy. The average dose of irradiation was 52.5 Gy. 29 cases of the same period of the same line of preservation of bladder surgery after mitomycin simple rule of bladder chemotherapy as a control (control group). Results In the study group, the other two patients were treated according to the plan except for 2 cases who continued treatment after radiation cystitis 3d and 1 week respectively. All cases were followed up for more than 3 years, with an average follow-up of 41.6 months. The 3-year pelvic recurrence rates in study group and control group were 18.8% and 44.8%, respectively (P = 0. 026). The 3 years distant metastasis rates were 18.2% and 21.1%, respectively (P = 0.437). The 3-year survival rates were 81.8% and 86.2%, respectively (P = .670). Conclusions Radiotherapy and chemotherapy after bladder cancer preservation can effectively reduce the pelvic recurrence rate of invading invasive bladder cancer, which is an ideal adjuvant therapy for bladder cancer after bladder preservation