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Michael加成反应是有机合成领域一类非常重要的反应.随着人们环保意识的增强和对绿色化学研究的深入,环境友好型Michael加成取得了诸多成功.综述了近5年来离子液体、酶催化、负载固相催化、聚乙二醇(PEG)等参与的Michael加成反应的研究进展.着重分析了反应体系的高效性、催化剂可能的催化反应机理以及催化剂的循环使用性,并以此对环境友好型Michael加成的发展做出了展望.
Michael addition reaction is a very important reaction in the field of organic synthesis.With the enhancement of people’s awareness of environmental protection and the deepening of the research on green chemistry, many achievements have been made in the environment-friendly Michael addition.This review summarizes the recent progress of ionic liquids, enzymes Catalyzed, supported solid-phase catalysis and polyethylene glycol (PEG) were reviewed.The high efficiency of the reaction system, the possible catalytic reaction mechanism of the catalyst and the recyclability of the catalyst were analyzed emphatically Outlook for the development of environmentally friendly Michael additions has been made.