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目的:探讨二手烟暴露对小鼠胃溃疡发展的影响。方法:将小白鼠随机分成5组:空白对照组(A)、二手烟对照组(B)、胃溃疡对照组(C)和正成型胃溃疡实验组(D)。A、B两组实验第30天处死小白鼠10只;C组在实验第6、10、30天分别处死小白鼠10只;D组在实验第6、10天分别处死小白鼠10只。显微观察胃壁组织,计算溃疡指数。结果:在第6天C组与D组溃疡指数无明显差异,第10天取样观察到D组溃疡指数显著高于C组。结论:二手烟暴露能促进胃溃疡的发展,且时间越长,影响越大。
Objective: To investigate the effects of secondhand smoke on the development of gastric ulcer in mice. Methods: The mice were randomly divided into 5 groups: blank control group (A), secondhand smoke control group (B), gastric ulcer control group (C) and positive gastric ulcer experimental group (D). Groups A and B were sacrificed on the 30th day. Ten mice were sacrificed on the 30th day. Ten mice were sacrificed on the 6th, 10th and 30th day in the group C, and 10 mice were killed in the D group on the 6th and 10th day. Microscopic observation of gastric wall tissue, calculate the ulcer index. Results: On the 6th day, there was no significant difference in ulcer index between C group and D group. On the 10th day, the ulcer index in D group was significantly higher than that in C group. Conclusion: Exposure to secondhand smoke can promote the development of gastric ulcer, and the longer the time, the greater the impact.