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为了研究阴虚阳虚状态下体温中枢调节过程是否受到影响,本文采用微电极细胞外记录方法观察阴虚和阳虚大鼠模型视前区—下丘脑前部(PO/AH)温度敏感神经元放电变化,发现阴虚大鼠冷敏神经元比例上升,阳虚大鼠热敏神经元比例上升,两者的神经元构成比与对照组相比,差异有显著性(X~2=18.41,P<0.01),阴虚和阳虚组神经元平均放电频率都低于对照组,神经元对热刺激的耐受性也低于对照组。以上结果提示:阴虚和阳虚大鼠体温中枢调节功能有一定程度下降,并伴有产热一散热失衡。
In order to study whether the body temperature central regulation process under yin deficiency and yang deficiency is affected, we used the microelectrode extracellular recording method to observe the preoptic area of hypothalamic (PO/AH) temperature-sensitive neurons in the yin deficiency and yang deficiency rat model. Changes in discharge showed that the proportion of cold-sensitive neurons in yin deficiency rats increased, and the proportion of heat-sensitive neurons in yang deficiency rats increased. There was a significant difference in the neuron composition ratio between the two groups compared with the control group (X~2=18.41, P<0.01), the average frequency of neurons in Yin deficiency and Yang deficiency group was lower than that in the control group, and the tolerance of neurons to thermal stimulation was also lower than that in the control group. The above results suggest that the regulatory function of central body temperature in yin deficiency and yang deficiency has declined to a certain extent, and there is an imbalance of heat production and heat dissipation.