颗粒溶素是定位于细胞毒性T淋巴细胞和自然杀伤细胞内的细胞毒性蛋白,是细胞免疫的重要效应分子。在宿主感染结核杆菌、细菌、真菌、病毒、原虫时,在体内均有高表达,与穿孔素协同对这些致病微生物具有杀灭作用。它的表达可反映机体抵抗感染性疾病所发生的细胞免疫水平,在抗感染中起着重要作用。在微生物广泛耐药的今天,颗粒溶素的发现,可能为临床抗感染开辟新的途径。 Granulysin is a cytotoxic protein localized in cytotoxic T lymphocytes and natural killer cells and is an important effector molecule for cellular immunity. In the host infected with Mycobacterium tuberculosis, bacteria, fungi, viruses, protozoa, are highly expressed in the body, and perforin in synergy on these pathogenic microorganisms have a killing effect. Its expression can reflect the level of cellular immunity that the body resists infectious diseases and play an important role in anti-infection. In today’s widespread microbial resistance, the discovery of granulysin may open up new avenues for clinical anti-infectives.