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目的探讨恶性肿瘤患者外周血单核淋巴细胞(PBMC)和肿瘤组织对临床常用化疗药物敏感相关性。方法采用MTT法检测118例恶性肿瘤患者PBMC和肿瘤组织对临床常用化疗药物敏感性,比较二者的相关性。结果肿瘤患者PBMC和肿瘤组织的肿瘤药物敏感性结果没有明显差别,测定的结果与临床常规化疗的结果基本一致。结论肿瘤患者PBMC可以替代肿瘤组织进行药物敏感性测定,结果可作为个性化治疗的理论依据。
Objective To investigate the sensitivity of peripheral blood mononuclear cells (PBMCs) and tumor tissues in patients with malignant tumors to commonly used chemotherapy drugs. Methods MTT assay was used to detect the sensitivity of PBMCs and tumor tissues to the commonly used chemotherapeutic drugs in 118 patients with malignant tumors. The correlation between them was compared. Results There was no significant difference in tumor drug sensitivity between PBMCs and tumor tissues in tumor patients, and the results were basically the same as the results of routine chemotherapy. Conclusion Tumor patients PBMC can replace the tumor tissue for drug sensitivity determination, the results can be used as a theoretical basis for personalized treatment.