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目的:观察苯甲酸雌二醇软膏联合盐酸氟西汀治疗女性更年期综合征的疗效和安全性。方法:将62例女性更年期综合征患者随机均分为试验组与对照组。试验组患者应用苯甲酸雌二醇软膏联合盐酸氟西汀治疗,对照组患者常规口服戊酸雌二醇片治疗,观察、比较两组患者的疗效及安全性。结果:治疗2个月后,两组患者Kupperman 11项评分均较治疗前显著下降(P<0.05),下降幅度组间比较差异无统计学意义(P>0.05);在治疗1、2个月时间点上,试验组患者汉密尔顿抑郁评分较治疗前显著下降,且下降幅度大于对照组(P<0.05)。治疗过程中,试验组患者不良反应发生率显著低于对照组(P<0.05)。结论:苯甲酸雌二醇软膏联合盐酸氟西汀治疗女性更年期综合征疗效较好,且不良反应发生率较低。
Objective: To observe the efficacy and safety of estradiol benzoate ointment combined with fluoxetine hydrochloride in the treatment of female climacteric syndrome. Methods: 62 cases of women with menopausal syndrome were randomly divided into experimental group and control group. The test group patients with estradiol benzoate ointment combined with fluoxetine hydrochloride treatment, the control group patients with conventional oral administration of estradiol valerate tablets were observed and compared the efficacy and safety of two groups of patients. Results: After 2 months of treatment, Kupperman scores of 11 patients in both groups were significantly lower than those before treatment (P <0.05), and there was no significant difference between the two groups (P> 0.05) At the time point, the Hamilton Depression Rating decreased significantly in experimental group compared with that before treatment, and the decreasing rate was greater than that in control group (P <0.05). During the course of treatment, the incidence of adverse reactions in the test group was significantly lower than that in the control group (P <0.05). Conclusion: The combination of estradiol benzoate ointment and fluoxetine hydrochloride is effective in treatment of menopausal syndrome and the incidence of adverse reactions is low.