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目的:采用高频彩色多普勒超声对类风湿关节炎患者(RA)颈动脉的血管内膜结构和血流动力进行监测,探讨超声在早期发现类风湿关节炎患者并发颈动脉粥样硬化中的应用价值。方法:应用高频超声测量45例类风湿关节炎患者及30例正常对照组的双侧颈动脉内-中膜厚度(IMT)及颈总动脉内径(Dn)、颈总动脉收缩期峰值流速(PSV)、舒张末期流速(EDV)、血流阻力指数(RI)、和搏动指数(PI),并进行统计分析。结果:RA患者颈动脉IMT及颈总动脉内径(Dn)较正常对照组明显增厚(0.84vs0.62,P<0.01)、增宽(0.84vs0.82,P<0.01);RA组颈动脉血流动力学改变较正常对照组比较差异无统计学意义(PSV:85.43vs 81.38;EDV:31.27vs33.41;RI:0.65vs0.67,P>0.05)。结论:彩色超声多普勒检查技术能够在RA患者早期发现颈部血管内膜结构及血流动力学的改变,能够早期反映颈部血管的硬化程度,为临床分析病情的发展及后期临床治疗方案提供指导。
OBJECTIVE: To monitor the intima-formation and hemodynamics of the carotid arteries of patients with rheumatoid arthritis (RA) by high-frequency color Doppler ultrasonography and to explore the relationship between ultrasound and carotid atherosclerosis in patients with early-stage rheumatoid arthritis The application value. Methods: The bilateral carotid intima - media thickness (IMT) and common carotid artery diameter (Dn) were measured in 45 patients with rheumatoid arthritis and 30 normal controls by high frequency ultrasound. Peak systolic velocity of common carotid artery PSV, EDV, RI and PI were measured and analyzed statistically. Results: The carotid artery IMT and the common carotid artery diameter (Dn) of RA patients were significantly thicker than that of the normal control group (0.84 vs 0.62, P <0.01), widened (0.84 vs 0.82, P <0.01) Hemodynamic changes compared with the normal control group showed no significant difference (PSV: 85.43vs 81.38; EDV: 31.27vs33.41; RI: 0.65vs0.67, P> 0.05). Conclusion: Color Doppler ultrasonography can detect the changes of endothelium structure and hemodynamics of neck in early stage of RA, and can reflect the degree of sclerosis of neck vessels at early stage. It is of great value in clinical analysis of clinical development and clinical treatment Provide guidance.