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某些哮喘患者服用阿斯匹林或其它解热镇痛药后而激发的哮喘的称为“阿斯匹林哮喘”。80%的病人见于成年人,女性多见。本病顽固、严重、甚者死亡。其发病机理尚未完全阐明,可能主要与该类药物抑制前列腺素(PG)的生物合成有关。现已知花生四烯酸有两条代谢途径,其一是通过环加氧酶合成PG(PGE具有松弛支气管平滑肌和对抗组织胺所引起的支气管收缩;其二是通过脂氧化酶生成白三烯(对支气管平滑肌具有收缩作用)。由于阿斯匹林等药物抑
Some patients with asthma who have been challenged with aspirin or other antipyretic and analgesic drugs are referred to as “aspirin asthma.” 80% of the patients found in adults, more common in women. The disease is stubborn, serious, and even death. Its pathogenesis has not been fully elucidated, and may be mainly related to the class of drugs that inhibit prostaglandin (PG) biosynthesis. It is known that arachidonic acid has two metabolic pathways, one is the synthesis of PG by cyclooxygenase (PGE has bronchial smooth muscle relaxation and bronchoconstriction induced by histamine; the other is the production of leukotrienes by lipoxygenase (Contraction of bronchial smooth muscle contraction.) As aspirin and other drugs suppressed