維生素B_1应用于临床迄今已近三十年。实践表明,維生素B_1在体內与組織的亲和力較小,进入血細胞的量极少,因此排泄快,在体內貯留的时間短暫,吸收量有一定限度,即使大剂量服用,多余的量仍然排出体外,不能获得按用量比例增加的效果。当体內有硫胺酶存在时,能 Vitamin B_1 has been used clinically for nearly three decades. Practice shows that vitamin B_1 in vivo and tissue affinity is small, the amount of blood cells into the very small, so excretion fast, short-term storage in the body, there is a certain amount of absorption, even at high doses, the amount of excess is still Excreted, can not be obtained by increasing the proportion of the effect. When the body has thiaminase, can