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目的:观察中剂量环磷酰胺(CTX)为主的联合化疗加G蛳CSF对恶性血液病患者自体外周血造血干细胞(APBSC)的动员效果。方法:31例患者接受中剂量CTX 2.2 g/m2(1.8 g/m2~3.0 g/m2)联合VP16(600 mg ~ 800 mg)或Ara蛳C(1.0 g/m2 ~ 2.0 g/m2)化疗,WBC降至最低值后开始皮下注射G蛳CSF 300 μg/d直至采集结束。WBC≥(3.0~5.0)×109/L时开始采集,当单个核细胞(MNC)累计≥3.8×108/kg或CD+34细胞≥2.0×106/kg时停止采集。结果:采集次数为(2.9±1.0)次,G蛳CSF持续应用时间为(7.4±2.0)d,采集到的MNC细胞数为(5.53±2.54)×108/kg,CD+34细胞数为(9.46±7.24)×106/kg,CFU蛳GM(46.02±70.58)×104/kg。全部移植患者造血功能均获满意重建。结论:中剂量CTX为主的联合化疗加同一剂量G蛳CSF对血液病患者的APBSC动员是安全、有效的。
Objective: To observe the mobilization effect of middle dose cyclophosphamide (CTX) combination chemotherapy combined with G 蛳 CSF on peripheral blood hematopoietic stem cells (APBSC) in patients with hematologic malignancies. Methods: Thirty-one patients underwent CTX 2.2 g / m 2 (1.8 g / m 2 ~ 3.0 g / m 2) combined with VP16 (600 mg ~ 800 mg) or Ara C (1.0 g / m 2 ~ 2.0 g / m 2) After the WBC was reduced to the minimum, G CSF CSF 300 μg / d was injected subcutaneously until the end of the collection. WBC ≥ (3.0 ~ 5.0) × 109 / L began to collect when the mononuclear cells (MNC) cumulative ≥ 3.8 × 108 / kg or CD + 34 cells ≥ 2.0 × 106 / kg stop collecting. RESULTS: The duration of G 蛳 CSF administration was (7.4 ± 2.0) d and the number of MNC cells was (5.53 ± 2.54) × 108 / kg and the number of CD + 34 cells was (2.9 ± 1.0) 9.46 ± 7.24) × 106 / kg, CFU 蛳 GM (46.02 ± 70.58) × 104 / kg. All patients with hematopoietic function were satisfactory reconstruction. Conclusion: CTX-based combination chemotherapy plus the same dose of G-CSF is safe and effective for APBSC mobilization in patients with hematological diseases.