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目的探讨肾阳虚对消化吸收功能的影响。方法切除大鼠双侧肾上腺的3/4复制肾阳虚动物模型,术后4周分为模型组和参附汤组,假手术组除不切除肾上腺外余同手术组,作为对照组。参附汤组大鼠灌胃给予参附汤水煎液,模型组和对照组给予等容量的生理盐水,灌胃4周。酶联免疫法检测血清GAS含量,间苯三酚法检测血清D-木糖含量。结果模型组大鼠血清GAS、D-木糖含量较对照组均显著降低(P<0.01),参附汤组大鼠GAS、D-木糖含量较对照组均显著升高(P<0.01)。结论肾阳虚模型大鼠消化吸收功能降低。
Objective To investigate the effect of kidney-yang deficiency on digestion and absorption. Methods Three-fourths of rat models with bilateral adrenal insufficiency were excised and divided into model group and Shenfu decoction group 4 weeks after operation. Sham operation group was divided into the same operation group and non-excision adrenal group as the control group. Shenfu Tang group rats were given Shenfu Decoction, model group and control group were given equal volume of saline, gavage for 4 weeks. Serum GAS content was detected by enzyme-linked immunosorbent assay and serum D-xylose content was measured by phloroglucinol method. Results The contents of GAS and D-xylose in the model group were significantly lower than those in the control group (P <0.01). The contents of GAS and D-xylose in the Shenfu decoction group were significantly higher than those of the control group (P <0.01) . Conclusion Kidney-yang deficiency rats have lower digestion and absorption function.