目的用介入的方法将自体骨髓干细胞移植入急性心肌梗死部位,观察其安全性及对心功能的改善情况。方法ST段抬高型急性心肌梗死(AMI)患者6例,行骨髓干细胞移植+经皮冠状动脉介入(PCI),患者于术前、术后查24 h动态心电图,术前、术后1周、2月、4月均查超声心动图,术后2月、4月行6min步行实验(6 MWT)等检查。结果6例移植患者术前、术后均无不良反应,4个月的观察,未发现新的心律失常,相反原有室性早搏的患者,其较前明显减少。左室射血分数(LVEF)随时间的延长而在增长,差异显著(P<0.05);术后2个月、4个月的6 MWT,差异显著(P<0.05)。结论经冠状动脉自身骨髓干细胞移植安全性好;左室收缩功能明显改善。 Objective To introduce autologous bone marrow stem cells into acute myocardial infarction by interventional method and observe its safety and improvement of cardiac function. Methods Six patients with ST-segment elevation acute myocardial infarction (AMI) underwent bone marrow stem cell transplantation and percutaneous coronary intervention (PCI). The patients underwent 24-hour ambulatory electrocardiogram before and after surgery. Preoperative and postoperative , Echocardiography was performed in February and April, and 6-minute walk test (6 MWT) was performed in February and April after operation. Results 6 cases of transplant patients had no adverse reactions before and after operation, 4 months of observation, no new arrhythmia was found. On the contrary, patients with premature ventricular contractions were significantly reduced compared with those before. The left ventricular ejection fraction (LVEF) increased with time, with significant difference (P <0.05). The 6 MWT at 2 months and 4 months after operation showed significant difference (P <0.05). Conclusions The transplanting of autologous bone marrow stem cells through coronary artery is safe and the left ventricular systolic function is obviously improved.