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目的研究MR灌注成像在脑星形细胞肿瘤术前分级中的应用价值。方法32例脑星形细胞肿瘤病人依次行常规MRI平扫、MR灌注成像及增强MRI。MR灌注成像采用动态增强T2鄢WI梯度回波-回波平面成像序列(T2鄢WIGRE-EPI),造影剂用量为0.2mmol/kg,注射流率为3￣4mL/s。首先得到信号强度-时间曲线,并合成相对脑血流容积(rCBV)图,计算出最大rCBV比率。独立样本t检验用于评价两组数据的差异,P<0.05认为有统计学意义。结果低级别星形细胞瘤(I￣II)18例,高级别星形细胞瘤(III￣IV)14例。低级别星形细胞瘤组最大rCBV比率为(2.57±0.78)1.44￣4.88,高级别星形细胞瘤组最大rCBV比率为(5.40±0.63)4.76￣7.07,两组之间比较有显著性差异(P<0.01)。结论MR灌注成像能有效地在术前评价星形细胞肿瘤的病理级别。
Objective To study the value of MR perfusion imaging in preoperative classification of brain astrocytic tumors. Methods Thirty two patients with brain astrocytoma underwent plain MRI, MR perfusion imaging and enhanced MRI. MR perfusion imaging using dynamic enhanced T2 Yan II gradient echo-echo planar imaging sequence (T2WIRE-EPI), the amount of contrast agent 0.2mmol / kg, injection rate of 3 ~ 4mL / s. First, the signal intensity-time curve was obtained and the relative rCBV map was synthesized to calculate the maximum rCBV ratio. Independent sample t-test was used to evaluate the difference between the two groups of data, P <0.05 was considered statistically significant. Results Low-grade astrocytoma (I ~ II) in 18 cases, high-grade astrocytoma (III ~ IV) in 14 cases. The highest rCBV ratio was (2.57 ± 0.78) 1.44 ~ 4.88 in the low-grade astrocytoma group, and the highest rCBV ratio in the high-grade astrocytoma group was (5.40 ± 0.63) 4.76-7.07. There was a significant difference between the two groups P <0.01). Conclusion MR perfusion imaging can effectively evaluate the pathological grade of astrocytic tumors preoperatively.