本文报告二例K型轻链型多发性骨髓瘤,尿中皆检出较多游离的K型轻链蛋白,伴血中各种正常免疫球蛋白偏低,骨髓中浆细胞明显增多,临床上有明显溶骨改变、肾功能衰退及高血钙症;对化疗反应较差。其中一例诊断后不久死于肾功能衰竭与感染。结合文献对该病的临床特征、免疫学发现、诊断及其肾病问题作了讨论。 This article reports two cases of K type light chain multiple myeloma, urine were detected more free K-type light chain protein, with a variety of normal immunoglobulin in the blood is low, significantly increased bone marrow plasma cells, clinically Significant changes in osteolytic, renal dysfunction and hypercalcemia; poor response to chemotherapy. One case died of kidney failure and infection shortly after diagnosis. Combined with the literature on the clinical features of the disease, immunological findings, diagnosis and kidney problems were discussed.