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[目的]观察黄芪鸡血藤汤对大鼠肝纤维化的预防作用,并探讨其机制。[方法]选用SD大鼠58只,随机分为5组,正常对照组(10只),正常饮食饮水,皮下注射花生油。模型组(12只):按复合因素造模。黄芪鸡血藤汤治疗组分为大、中、小剂量组(每组12只):在造模的同时每日分别给予中药粉剂2、10、.5 g/100 g体重灌胃。8周末,光镜下观察各组大鼠肝脏组织学改变,并进行比较。免疫组化法观察黄芪鸡血藤汤对各组大鼠肝脏转化生长因子β1(TGF-β1)、结缔组织生长因子(CTGF)、血小板衍生生长因子(PDGF-BB)表达的影响。[结果]8周后,中药各剂量组大鼠肝脏色泽、质地、表面光滑程度均明显优于模型组;肝细胞损伤及肝纤维化增生程度明显低于模型组(P<0.05),大剂量组最低(P<0.01);TGF-β1、CTGF、PDGF-BB在大鼠肝组织中的表达明显低于模型组(P<0.05),大剂量组最低(P<0.01)。[结论]黄芪鸡血藤汤能有效的预防大鼠肝纤维化的形成,它可能通过降低TGF-β1、CTGF、PDGF-BB的表达,抑制星状细胞的活化而起作用。
[Objective] To observe the preventive effect of Huangqi Chicken Xitan Decoction on hepatic fibrosis in rats and explore its mechanism. [Methods] Fifty-eight SD rats were randomly divided into 5 groups, normal control group (10 rats), normal drinking water and subcutaneous injection of peanut oil. Model group (12): Modeled by composite factors. The treatment components of Huangqi Chicken Blood Teng Decoction were large, medium and small dose groups (12 in each group): At the same time, the rats were given intragastric administration of 2, 10, and 5 g/100 g body weight separately. At the end of the 8th week, histological changes in the liver of each group were observed under light microscope and compared. Immunohistochemical method was used to observe the effect of Huangqiqixietang decoction on the expression of TGF-β1, CTGF and PDGF-BB in rats. [Results] After 8 weeks, the liver color, texture and surface smoothness of the rats in each dose group of traditional Chinese medicine were significantly better than those in the model group; the degree of liver cell damage and hepatic fibrosis was significantly lower than that in the model group (P<0.05). The lowest was in the group (P<0.01); the expression of TGF-β1, CTGF, and PDGF-BB in the rat liver tissue was significantly lower than that in the model group (P<0.05), and the highest dose group was the lowest (P<0.01). [Conclusion] Huangqi Chicken Xitan Decoction can effectively prevent the formation of hepatic fibrosis in rats, which may play a role by reducing the expression of TGF-β1, CTGF, PDGF-BB and inhibiting the activation of stellate cells.