目的:采用RP-HPLC法测定盐酸氨溴索口服液的含量。方法:用Shim-pack CLC-ODS柱,以甲醇-水-冰醋酸(40:60:1)为流动相,UV检测波长为 244 nm,室温下测定盐酸氨溴索口服液含量。结果:盐酸氨溴索在 2～10μg·ml~(-1)范围内呈良好线性关系,r=0.999 9,回收率为99.8％,RSD为0.5％(n=5)。结论:方法专属性强、简便,能满足制剂质量标准的要求。 Objective: To determine the content of ambroxol hydrochloride oral liquid by RP-HPLC. Methods: Shim-pack CLC-ODS column was used with methanol-water-glacial acetic acid (40: 60: 1) as mobile phase and UV detection wavelength was 244 nm. Ambroxol hydrochloride oral solution was determined at room temperature. Results: Ambroxol hydrochloride showed good linearity in the range of 2 ~ 10μg · ml ~ (-1) with r = 0.999 9, recovery of 99.8% and RSD of 0.5% (n = 5). Conclusion: The method is unique, simple and can meet the requirements of preparation quality standards.