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以唾液17-羟孕酮(17-OHP)对先天性肾上腺皮质增生症(CAH)5例进行治疗监测。其中男3例,女2例。年龄3.9～12.5岁,4例为 CAH 失盐型,1例为 CAH 非失盐型。用可磁化固相抗体17-羟孕酮快速 RIA 法测定唾液17-OHP,并定期随访唾液17-OHP 以调整激素剂量。同时定期随访身高、体重、血睾酮和骨龄。随访时间为1年到3年半。观察结果:①唾液17-OHP 测定简便、快速、易被患儿接受且较可靠。②定期随访唾液17-OHP 对调整激素用量有一定意义。③CAH 患者对激素治疗需要量存在个体差异,氢化可的松需要量从0.7～1.0mg/kg·d 不等,但不宜大于1.2mg/kg·d。失盐型患者晚上加用9α-氟氩可的松(0.03～0.05mg)者治疗效果较好。
Five patients with congenital adrenal hyperplasia (CAH) were treated with salivary 17-hydroxyprogesterone (17-OHP). There were 3 males and 2 females. Age 3.9 to 12.5 years old, 4 cases of CAH loss of salt type, 1 case of CAH non-salt type. Salivary 17-OHP was measured by the rapid RIA method of the magnetizable solid phase antibody 17-hydroxyprogesterone, and the hormone dose was adjusted by regularly following the saliva 17-OHP. At the same time regular follow-up height, weight, blood testosterone and bone age. Follow-up time was 1 year to 3 years and a half. Observations: ① saliva 17-OHP determination of simple, fast, easily accepted by children and more reliable. ② regular follow-up saliva 17-OHP on the amount of hormone adjustment has some significance. ③CAH patients need to hormone therapy there are individual differences, hydrocortisone need ranging from 0.7 ~ 1.0mg / kg · d, but not more than 1.2mg / kg · d. Patients with loss of salt at night with 9α-fluoro argon cortisone (0.03 ~ 0.05mg) were better treatment.