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[目的]观察胃癌腹腔转移患者应用腹腔热灌注化疗联合体外高频热疗的临床疗效和不良反应。[方法]应用5-Fu﹑DDP行腹腔热灌注,化疗第2d行腹腔局部热疗60min,温度控制在43℃。[结果]实体肿瘤治疗有效率57.14%(12/21),腹水控制有效率85.71%(6/7),腹痛症状缓解率90.00%(9/10)。不良反应为Ⅱ度白细胞下降17.39%(4/23),化学性腹膜炎8.70%(2/23),胃肠道反应17.39%(4/23)。[结论]腹腔热灌注化疗联合高频热疗治疗胃癌腹腔转移,近期疗效好,不良反应小。
[Objective] To observe the clinical efficacy and adverse reactions of intraperitoneal hyperthermic perfusion chemotherapy combined with external high frequency hyperthermia in patients with gastric cancer with peritoneal metastasis. [Methods] Peritoneal hyperthermic perfusion was performed with 5-Fu and DDP. Local hyperthermia was performed for 60 min on the 2nd day after chemotherapy and the temperature was controlled at 43 ° C. [Results] The effective rate of solid tumor treatment was 57.14% (12/21), the effective rate of ascites control was 85.71% (6/7), and the rate of relieving abdominal pain was 90.00% (9/10). Adverse reactions were grade II leukopenia 17.39% (4/23), chemical peritonitis 8.70% (2/23), gastrointestinal reaction 17.39% (4/23). [Conclusion] Intraperitoneal hyperthermic perfusion chemotherapy combined with high frequency hyperthermia in peritoneal metastasis of gastric cancer has good short-term curative effect and small adverse reaction.