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目的探讨菌血症患者中性粒细胞VCS参数的变化及意义。方法采用BECKMAN COULTERLH750血细胞分析仪检测51例菌血症患者及64例健康体检者的白细胞数及中性粒细胞VCS参数,分析菌血症患者治疗前、后白细胞数、中性粒细胞平均体积(MNV)、平均电导率(MNC)、平均激光散射值(MNS)和体积分布宽度(NDW)参数的变化。结果菌血症组(治疗前)与正常对照组比较WBC、MNV、MNC、NDW增高,MNS降低,差异有统计学意义(P<0.05);菌血症组(治疗后)与正常对照组比较各参数差异无统计学意义(P>0.05)。WBC≤10×109/L并且NE≤70%组和WBC>10×109/L并且NE>70%组治疗前VCS参数与正常对照组比较均有差异,差异有统计学意义(P<0.05);治疗后与正常对照组比较差异无统计学意义(P>0.05)。结论中性粒细胞的VCS参数能反映菌血症患者血液中性粒细胞的形态学变化,对菌血症患者的诊疗具有一定的临床指导意义。
Objective To investigate the changes and significance of neutrophil VCS parameters in patients with bacteremia. Methods BECKMAN COULTER LH750 hematology analyzer was used to detect leukocyte count and neutrophil VCS parameters in 51 patients with bacteremia and 64 healthy subjects. The leukocyte count, neutrophil average volume MNV, MNC, MNS and NDW parameters. Results Compared with the normal control group, the levels of WBC, MNV, MNC, NDW increased and MNS decreased in the bacteremia group (before treatment) and the difference was statistically significant (P <0.05). Compared with the normal control group, the bacteremia group There was no significant difference between the parameters (P> 0.05). WBC≤10 × 109 / L and NE≤70%, WBC> 10 × 109 / L and NE> 70%, the difference was statistically significant (P <0.05) There was no significant difference between the two groups after treatment (P> 0.05). Conclusions The VCS parameters of neutrophils can reflect the morphological changes of blood neutrophils in patients with bacteremia, which is of clinical significance for the diagnosis and treatment of patients with bacteremia.